{"id":93,"date":"2020-10-08T02:35:37","date_gmt":"2020-10-08T02:35:37","guid":{"rendered":"http:\/\/wolfson.net\/clgenetics\/?page_id=93"},"modified":"2021-05-17T02:58:28","modified_gmt":"2021-05-17T02:58:28","slug":"g-banded-karyotyping","status":"publish","type":"page","link":"https:\/\/wolfson.net\/clgenetics\/services\/g-banded-karyotyping\/","title":{"rendered":"G-Banded Karyotyping"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.6.6&#8243; background_color=&#8221;#f7f7f4&#8243; custom_padding=&#8221;||30px|||&#8221;][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.6.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; custom_margin=&#8221;||30px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;500ms&#8221;]<\/p>\n<h1>G-Banded Karyotyping<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.6.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text ul_item_indent=&#8221;5%&#8221; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; ul_font=&#8221;||||||||&#8221; ul_font_size=&#8221;12px&#8221; ul_line_height=&#8221;1.8em&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; custom_margin=&#8221;||30px|||&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;]<\/p>\n<p>Cell Line Genetics (CLG) is recognized world-wide for its expertise in cell line karyotyping analysis. Unlike most cytogenetic core facilities and commercial laboratories focused on clinical testing, CLG provides cell therapy and regenerative medicine researchers with the highest quality cytogenetics service available with guaranteed, fast turn-around time.<\/p>\n<p><strong>What is Karyotyping?<\/strong><br \/>Karyotyping is an essential tool for ensuring genetic integrity, determining copy number variances (CNV), deletions and translocations (balanced and unbalanced). It is still regarded as the gold standard for copy number variance detection. Karyotyping pairs and aligns all the homologous chromosomes within a cell. From this, a cytogeneticist can analyze several forms of structural genetic aberrations.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_gallery gallery_ids=&#8221;15&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221; auto=&#8221;on&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.6.6&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#efefe9&#8243; min_height=&#8221;20px&#8221; height=&#8221;20px&#8221; max_height=&#8221;20px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.2&#8243; background_color=&#8221;#f7f7f4&#8243; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221;][et_pb_row _builder_version=&#8221;4.6.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text ul_item_indent=&#8221;5%&#8221; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; ul_font=&#8221;||||||||&#8221; ul_font_size=&#8221;16px&#8221; ul_line_height=&#8221;1.8em&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;]<\/p>\n<p>CLG\u2019s scientists are clinically trained and experienced in cell genomic stability analysis and structural chromosomal anomalies unique to various types of cell lines\u2014many of which can lead to invasive cell populations and other adverse genetic events. Since the company\u2019s inception, CLG has characterized thousands of research and therapeutic cell lines including:<\/p>\n<ul>\n<li>Stem Cells (e.g., Embryonic, Induced Pluripotent, Hematopoietic)<\/li>\n<li>Primary Cells, CAR-T Cells and NK Cells<\/li>\n<li>Gene-Edited Cells (CRISPR-Cas9 or ZFN)<\/li>\n<li>Multiple Species (e.g., Human, Mouse, Rat, Rhesus)<\/li>\n<\/ul>\n<p>Cell Line Genetics, in partnership with Leica Biosystems, uses the latest version of the Cytovision GSL-120 image analysis and capture system. The GSL-120 is an integrated, scalable platform that allows for consistent, replicable results across all samples.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjgyIn19@&#8221; button_text=&#8221;Contact us for more information&#8221; button_alignment=&#8221;center&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.3&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#4595CF&#8221; button_border_color=&#8221;RGBA(0,0,0,0)&#8221; button_font=&#8221;|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; custom_margin=&#8221;0px||20px||false|false&#8221; custom_padding=&#8221;10px|50px|10px|50px|false|false&#8221; global_module=&#8221;239450&#8243;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; 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body_letter_spacing=&#8221;0.2px&#8221; body_line_height=&#8221;30px&#8221; hover_enabled=&#8221;0&#8243; custom_css_tabs_controls=&#8221;position: relative;||background: none;||margin-bottom: 8px;||perspective: 17em;&#8221; custom_css_tab=&#8221;margin-right: 10px;||border: 0px solid #9b9da0 ;||||&#8221; custom_css_tabs_content=&#8221;text-transform: capitalize;||border: 2px solid #9b9da0 ;||height: 100%;&#8221; border_width_all=&#8221;0px&#8221; locked=&#8221;off&#8221; tab_text_color__hover_enabled=&#8221;on|hover&#8221; tab_text_color__hover=&#8221;#ffffff&#8221; inactive_tab_background_color__hover_enabled=&#8221;on|desktop&#8221; inactive_tab_background_color__hover=&#8221;#4595CF&#8221; custom_css_tab_last_edited=&#8221;on|desktop&#8221; custom_css_tab_tablet=&#8221;display: grid;||margin-right: 0px;||margin-bottom: 10px;||border-bottom: none;||width: 100%;||border-right:none;&#8221; active_tab_background_color__hover_enabled=&#8221;on|hover&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_tab title=&#8221;Attributes&#8221; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; custom_css_after=&#8221;border: none;&#8221;]<\/p>\n<ul>\n<li>Live cell cultures and metaphase cell pellets accepted for chromosome analysis.<\/li>\n<li>Chromosome analysis of 20 cells per cell line.<\/li>\n<li>High quality G-band karyotype images in publication ready format.<\/li>\n<li>Comprehensive interpretation of results by a CLG scientist.<\/li>\n<li>Report reviewed and signed by Clinical Certified Cytogeneticist upon request.<\/li>\n<li>Results securely stored in CLG database.<\/li>\n<li>7-10 day turn around \u2013 <strong>Rush services are available.<\/strong><\/li>\n<li>Both Research Use Only (RUO) and Good Laboratory Practice (GLP) service available.<\/li>\n<\/ul>\n<p>[\/et_pb_tab][et_pb_tab title=&#8221;Service Specs&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; custom_css_after=&#8221;border: none;&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\"><strong>Used to:<\/strong><\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>As a baseline screen:\n<ul>\n<li>When cell lines are derived<\/li>\n<li>Before the start of an experiment<\/li>\n<li>At the conclusion of an experiment<\/li>\n<li>Before publication<\/li>\n<li>As part of routine cell line QC<\/li>\n<li>As part of cell banking QC<\/li>\n<\/ul>\n<\/li>\n<li>When cultures show unusual growth properties<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\"><b><span lang=\"EN-CA\">Detects:<\/span><\/b><\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Microscopic aberrations &gt;5Mb<\/li>\n<li>Chromosome abnormalities:\n<ul>\n<li>Aneuploidy<\/li>\n<li>Inversions<\/li>\n<li>Duplications\/deletions<\/li>\n<li>Translocations<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Doesn\u2019t Detect:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>\n<div><span lang=\"EN-CA\">Submicroscopic aberrations &lt;5Mb in size<\/span><\/div>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Sample Requirements:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Live Cell Culture (T-25 Flask)<\/li>\n<li>Cell pellets<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Species:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Human<\/li>\n<li>Mouse<\/li>\n<li>Various Primates<\/li>\n<li>Rat<\/li>\n<li>Cow<\/li>\n<li>Pig<\/li>\n<li>Rabbit<\/li>\n<li>Cat<\/li>\n<li><strong><a href=\"\/contact\">Contact us about other species<\/a><\/strong><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Turnaround:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>\n<div><span lang=\"EN-CA\">7 &#8211; 10 business days <b>RUSH services available<\/b><\/span><\/div>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_tab][et_pb_tab title=&#8221;Sample Requirements&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; custom_css_after=&#8221;border: none;&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>PROCEDURE: <\/strong><a href=\"https:\/\/www.clgenetics.com\/wp\/wp-content\/uploads\/2017\/11\/Mailing-Live-Cultures-2.12.16.pdf\">Mailing Live Cultures for Karyotyping<\/a><\/p>\n<p><strong>Requisition Form<\/strong><br \/>Each sample must be accompanied by its own Test Requisition Form. 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Unlike most cytogenetic core facilities and commercial laboratories focused on clinical testing, CLG provides cell therapy and regenerative medicine researchers with the highest quality cytogenetics service available with guaranteed, fast turn-around time. What is Karyotyping?Karyotyping is an essential tool [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":90,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\r\n<p>Cell Line Genetics (CLG) is recognized world-wide for its expertise in cell line karyotyping analysis. Unlike most cytogenetic core facilities and commercial laboratories focused on clinical testing, CLG is dedicated to providing cell therapy and regenerative medicine researchers with the highest quality cytogenetics service available with fast turn-around guaranteed.<\/p>\r\n<p>What is Karyotyping?<\/p>\r\n<p><PLACE CONTENT HERE. INCLUDE PICTURE><\/p>\r\n<p>Cell Line Genetics' scientists are clinically trained and experienced in cell genomic stability analysis and structural chromosomal anomalies unique to various types of cell lines\u2014many of which can lead to invasive cell populations and other adverse genetic events. Since the company\u2019s inception, Cell Line Genetics has characterized thousands of research and therapeutic cell lines including:<\/p>\r\n<ul>\r\n<li>Stem Cells (Embryonic, Induced Pluripotent, Hematopoietic)<\/li>\r\n<li>Primary Cells\u00a0<\/li>\r\n<li>CAR-T Cells\u00a0<\/li>\r\n<li>N\/K Cells\u00a0<\/li>\r\n<li>Gene-Edited Cells (CRISP-Cas9)<\/li>\r\n<li>Multiple Species (Human, Mouse, Rat, Rhesus)<\/li>\r\n<\/ul>\r\n<p>Feel free to contact us at <page><\/p>\r\n<p><Attributes> <Service Specs> <Sample Requirements><\/p>\r\n<p>\u00a0<\/p>\r\n<!-- \/wp:paragraph -->","_et_gb_content_width":"1080","inline_featured_image":false,"footnotes":""},"class_list":["post-93","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>G-Banded Karyotyping -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wolfson.net\/clgenetics\/services\/g-banded-karyotyping\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"G-Banded Karyotyping -\" \/>\n<meta property=\"og:description\" content=\"G-Banded KaryotypingCell Line Genetics (CLG) is recognized world-wide for its expertise in cell line karyotyping analysis. Unlike most cytogenetic core facilities and commercial laboratories focused on clinical testing, CLG provides cell therapy and regenerative medicine researchers with the highest quality cytogenetics service available with guaranteed, fast turn-around time. 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