{"id":239468,"date":"2021-05-16T18:39:27","date_gmt":"2021-05-16T18:39:27","guid":{"rendered":"http:\/\/wolfson.net\/clgenetics\/?page_id=239468"},"modified":"2021-05-19T13:52:16","modified_gmt":"2021-05-19T13:52:16","slug":"array-comparative-genomic-hybridization-acgh","status":"publish","type":"page","link":"https:\/\/wolfson.net\/clgenetics\/services\/array-comparative-genomic-hybridization-acgh\/","title":{"rendered":"Array Comparative Genomic Hybridization (aCGH)"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.3&#8243; background_color=&#8221;#f7f7f4&#8243; custom_padding=&#8221;||30px||false|false&#8221;][et_pb_row column_structure=&#8221;3_4,1_4&#8243; _builder_version=&#8221;4.9.3&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; custom_margin=&#8221;||30px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;500ms&#8221;]<\/p>\n<h1>Array Comparative Genomic Hybridization (aCGH)<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; _builder_version=&#8221;4.6.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text ul_item_indent=&#8221;5%&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; ul_font=&#8221;||||||||&#8221; ul_font_size=&#8221;12px&#8221; ul_line_height=&#8221;1.8em&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; custom_margin=&#8221;||30px|||&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;]Array Comparative Genomic Hybridization (aCGH) is a high-resolution karyotype analysis solution for the detection of unbalanced structural and numerical chromosomal alterations with high-throughput capabilities. Addition of SNPs can also detect polyploidy, loss of heterozygosity, and uniparental dysomy. It is especially useful as it can detect these aberrations at such a high resolution and on the genome level. The test also generates quantitative data which can be used for computational biology.<\/p>\n<p><strong>What is Array Comparative Genomic Hybridization (aCGH)?<\/strong><br \/>\nArray Comparative Genomic Hybridization is used to determine relative copy number variations between a test sample and reference genomic DNA. Reference or control DNA samples are fluor-labeled in one color, and the DNA of interest is labeled with another color. The two genomes are co-hybridized onto an array of DNA fragments. The relative signal intensity correlates to copy number ratio. Although, aCGH gives relative information on copy number between the genome of interest and the references genome, FISH can further be utilized to determine exact copy number in a region of interest. [\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_gallery gallery_ids=&#8221;15&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221; auto=&#8221;on&#8221;][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/wolfson.net\/clgenetics\/wp-content\/uploads\/2021\/05\/Array-CGH-v050321-3.jpg&#8221; alt=&#8221;CLG StemCheck\u2122 FISH Probe 1\/20&#8243; title_text=&#8221;Array CGH v050321 3&#8243; align=&#8221;center&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; module_alignment=&#8221;center&#8221; custom_padding=&#8221;|10%||10%|false|false&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;]<\/p>\n<p>CLG offers two different array comparative genomic hybridization arrays to help characterize your cell lines. CLG utilizes Agilent\u2019s Microarray platform. Complementary FISH validation services for aCGH studies are available. (See FISH services for further information).<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.6.6&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#efefe9&#8243; min_height=&#8221;20px&#8221; height=&#8221;20px&#8221; max_height=&#8221;20px&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.2&#8243; background_color=&#8221;#f7f7f4&#8243; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221;][et_pb_row _builder_version=&#8221;4.9.3&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.3&#8243; custom_padding=&#8221;||0px||false|false&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text ul_item_indent=&#8221;5%&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; ul_font=&#8221;||||||||&#8221; ul_font_size=&#8221;16px&#8221; ul_line_height=&#8221;1.8em&#8221; header_font=&#8221;|800||on|||||&#8221; header_text_color=&#8221;#4595cf&#8221; header_font_size=&#8221;40px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; animation_style=&#8221;fade&#8221; animation_delay=&#8221;900ms&#8221;]<\/p>\n<h2><strong>Services:<\/strong><\/h2>\n<ul>\n<li><strong>SurePrint G3 Human CGH Microarray Kit, 8x60K<\/strong>: High-throughput, low-cost alternative to karyotyping. Average coverage every 41KB with increased coverage in Refseq genes (33KB)<\/li>\n<li><strong>SurePrint G3 Human Genome CGH+SNP Microarray Kit, 4x180K<\/strong>: High resolution array with SNPs included. Average coverage every 25KB with increased coverage in ISCA regions (5KB)<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIzOTU0OCJ9fQ==@&#8221; button_text=&#8221;Submit Samples for Testing&#8221; button_alignment=&#8221;center&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.4&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;16px&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#4595CF&#8221; button_border_color=&#8221;RGBA(0,0,0,0)&#8221; button_font=&#8221;|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; custom_margin=&#8221;0px||20px||false|false&#8221; custom_padding=&#8221;10px|50px|10px|50px|false|false&#8221; global_module=&#8221;239450&#8243; saved_tabs=&#8221;all&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Tab_Style_26&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#F7F7F4&#8243; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221;][et_pb_row admin_label=&#8221;TAB MODULE TEMPLATE 26&#8243; _builder_version=&#8221;4.5.6&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.5.6&#8243; _module_preset=&#8221;default&#8221; custom_css_main_element_last_edited=&#8221;on|tablet&#8221; custom_css_main_element_tablet=&#8221;||&#8221;][et_pb_tabs active_tab_background_color=&#8221;#434343&#8243; inactive_tab_background_color=&#8221;#D7D7D7&#8243; active_tab_text_color=&#8221;#ffffff&#8221; admin_label=&#8221;Style 26&#8243; module_class=&#8221;et_pb_tabs_dct_3_26&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; tab_text_color=&#8221;#808080&#8243; body_text_align=&#8221;justify&#8221; body_text_color=&#8221;#808080&#8243; body_letter_spacing=&#8221;0.2px&#8221; body_line_height=&#8221;30px&#8221; custom_css_tabs_controls=&#8221;position: relative;||background: none;||margin-bottom: 8px;||perspective: 17em;&#8221; custom_css_tab=&#8221;margin-right: 10px;||border: 0px solid #9b9da0 ;||||&#8221; custom_css_tabs_content=&#8221;text-transform: capitalize;||border: 2px solid #9b9da0 ;||height: 100%;&#8221; border_width_all=&#8221;0px&#8221; locked=&#8221;off&#8221; tab_text_color__hover_enabled=&#8221;on|hover&#8221; tab_text_color__hover=&#8221;#ffffff&#8221; inactive_tab_background_color__hover_enabled=&#8221;on|desktop&#8221; inactive_tab_background_color__hover=&#8221;#4595CF&#8221; custom_css_tab_last_edited=&#8221;on|desktop&#8221; custom_css_tab_tablet=&#8221;display: grid;||margin-right: 0px;||margin-bottom: 10px;||border-bottom: none;||width: 100%;||border-right:none;&#8221; active_tab_background_color__hover_enabled=&#8221;on|hover&#8221;][et_pb_tab title=&#8221;Attributes&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_css_after=&#8221;border: none;&#8221;]<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr style=\"background-color: dddddd;\">\n<td style=\"width: 50%;\">\n<div><b><span lang=\"EN-CA\">SurePrint G3 Human CGH Microarray Kit, 8x60K<\/span><\/b><\/div>\n<\/td>\n<td width=\"312\" style=\"width: 79.91004497751123%;\"><strong>SurePrint G3 Human Genome CGH+SNP Microarray Kit, 4X180K<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: fff;\">\n<td style=\"width: 20%;\">\n<ul>\n<li>Arrays contain optimized, validated probes, and internal quality control features.<\/li>\n<li>55,077 distinct genomic probes.<\/li>\n<li>41 kb median probe spacing.<\/li>\n<li>60K probes.<\/li>\n<li>1000 replicates of biological probes.<\/li>\n<li>Graphical and quantitative data included in report.<\/li>\n<li>Results securely stored in CLG database.<\/li>\n<li>7-10 day turn around \u2013 <strong>Rush services are available.<\/strong><\/li>\n<li>Research Use Only (RUO) or Good Laboratory Practices (GLP) services are available.<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 79.91004497751123%;\">\n<ul>\n<li>Arrays contain optimized, validated probes, and internal quality control features.<\/li>\n<li>110,712 (CGH) and 59,647 (SNP) distinct genomic probes.<\/li>\n<li>25.3 kb median probe spacing.<\/li>\n<li>180K probes.<\/li>\n<li>3000 replicates of biological probes.<\/li>\n<li>Graphical and quantitative data included in report Results securely stored in CLG database.<\/li>\n<li>7-10 day turn around \u2013 <strong>Rush services are available.<\/strong><\/li>\n<li><span>Research Use Only (RUO) or Good Laboratory Practices (GLP) services are available<\/span>.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_tab][et_pb_tab title=&#8221;Service Specs&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_css_after=&#8221;border: none;&#8221;]<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\"><strong>\u00a0<\/strong><\/td>\n<td style=\"width: 79.88560533841755%; text-align: center;\"><strong>Standard FISH Services<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 20%;\"><strong>Used to:<\/strong><\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>As an adjunct to G-Band Karyotyping:<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>To identify complex chromosome aberrations<\/li>\n<li>To identify small partial trisomies<\/li>\n<li>To identify small marker chromosomes<\/li>\n<li>To refine chromosome breakpoints<\/li>\n<li>\n<div><span lang=\"EN-CA\">To detect small emerging abnormal clones<\/span><\/div>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\"><b><span lang=\"EN-CA\">Detects:<\/span><\/b><\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Genomic sequences of interest:<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Duplications and deletions &gt;40KB<\/li>\n<li>Low level mosaicism<\/li>\n<li>Unbalanced translocations<\/li>\n<li>Cryptic chromosome aberrations<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Doesn\u2019t Detect:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>\n<div><span lang=\"EN-CA\">Chromosome aberrations other than the probe sequence of interest<\/span><\/div>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Sample Requirements:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Live Cell Culture (T-25 Flask)<\/li>\n<li>Frozen Cells<\/li>\n<li><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Species:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>Human<\/li>\n<li>Mouse<\/li>\n<li>Contact us about other species<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 20%;\">\n<div><b><span lang=\"EN-CA\">Turnaround:<\/span><\/b><\/div>\n<\/td>\n<td style=\"width: 79.88560533841755%;\">\n<ul>\n<li>\n<div><span lang=\"EN-CA\">7 &#8211; 10 business days <\/span><\/div>\n<\/li>\n<li>\n<div><span lang=\"EN-CA\"><b>RUSH services available<\/b><\/span><\/div>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_tab][et_pb_tab title=&#8221;Sample Requirements&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_css_after=&#8221;border: none;&#8221;]<\/p>\n<p><strong>PROCEDURE: <\/strong><span lang=\"EN-CA\"><a href=\"http:\/\/wolfson.net\/clgenetics\/wp-content\/uploads\/2021\/05\/Mailing-Live-Cultures-2.12.16.pdf\" target=\"_blank\" rel=\"noopener\"><span>Mailing Live Cultures For FISH<\/span><\/a><\/span><\/p>\n<p><strong>Requisition Form<\/strong><br \/>Each sample must be accompanied by its own Test Requisition Form. Fill out a requisition form <a title=\"Request for Cell Line Characterization\" href=\"#\">here<\/a>.<\/p>\n<p>[\/et_pb_tab][et_pb_tab title=&#8221;References&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; body_ol_item_indent=&#8221;5px&#8221; body_ol_text_align=&#8221;left&#8221; body_ol_line_height=&#8221;1.5em&#8221; custom_css_after=&#8221;border: none;&#8221;]<\/p>\n<ol>\n<li>Merz, M., Jauch, A., Hielscher, T., Mai, E. K., Seckinger, A., Hose, D., Bertsch, U., Neben, K., Raab, M. S., Salwender, H., Blau, I. W., Lindemann, H. W., Schmidt-Wolf, I., Scheid, C., Haenel, M., Weisel, K., Goldschmidt, H., &amp; Hillengass, J. (2017). Longitudinal fluorescence\u00a0<em>in situ<\/em>hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation.\u00a0<em>Haematologica<\/em>,\u00a0<em>102<\/em>(8), 1432\u20131438. <a href=\"https:\/\/doi.org\/10.3324\/haematol.2017.168005\">doi.org\/10.3324\/haematol.2017.168005<\/a><\/li>\n<li>Shakoori A. R. (2017). Fluorescence In Situ Hybridization (FISH) and Its Applications.\u00a0<em>Chromosome Structure and Aberrations<\/em>, 343\u2013367. <a href=\"https:\/\/doi.org\/10.1007\/978-81-322-3673-3_16\">doi.org\/10.1007\/978-81-322-3673-3_16<\/a><\/li>\n<\/ol>\n<p>[\/et_pb_tab][\/et_pb_tabs][dvmd_table_maker tbl_column_header_count=&#8221;0&#8243; tbl_row_header_count=&#8221;0&#8243; tbl_row_min_height=&#8221;20px&#8221; tbl_stripes_active=&#8221;on&#8221; tbl_stripes_brightness=&#8221;114%&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; tbl_chead_text_font=&#8221;|700|||||||&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243; disabled_on=&#8221;on|on|on&#8221; disabled=&#8221;on&#8221;][dvmd_table_maker_item col_label=&#8221;SurePrint G3 Human CGH Microarray Kit, 8x60K&#8221; col_content=&#8221;SurePrint G3 Human CGH Microarray Kit, 8x60K<br \/>\n\u2022\tArrays contain optimized, validated probes, and internal quality control features.<br \/>\n\u2022\t55,077 distinct genomic probes.<br \/>\n\u2022\t41 kb median probe spacing.<br \/>\n\u2022\t60K probes.<br \/>\n\u2022\t1000 replicates of biological probes.<br \/>\n\u2022\tGraphical and quantitative data included in report.<br \/>\n\u2022\tResults securely stored in CLG database.<br \/>\n\u2022\t7-10 day turn around \u2013 Rush services are available.<br \/>\n\u2022\tResearch Use Only (RUO) or Good Laboratory Practices (GLP) services are available.<br \/>\n&#8221; 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Addition of SNPs can also detect polyploidy, loss of heterozygosity, and uniparental dysomy. It is especially useful as it can detect these aberrations at such a high [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":90,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\r\n<p>Cell Line Genetics (CLG) is recognized world-wide for its expertise in cell line karyotyping analysis. Unlike most cytogenetic core facilities and commercial laboratories focused on clinical testing, CLG is dedicated to providing cell therapy and regenerative medicine researchers with the highest quality cytogenetics service available with fast turn-around guaranteed.<\/p>\r\n<p>What is Karyotyping?<\/p>\r\n<p><PLACE CONTENT HERE. 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